Titre : Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis.

La conférence sera prononcée en anglais par le professeur Matthew Sigman du Département de chimie de l'University of Utah. Elle est commanditée par le Centre en chimie verte et catalyse (CCVC)

Résumé : Critical to the development of catalysts with practical potential in synthetic chemistry is a fundamental understanding of the mechanistic features which lead to a robust and selective catalytic system.  Within this regard, our group has focused on the development of new palladium catalysts for various oxidation and cross-coupling reactions wherein mechanistic analysis has played a vital role in catalyst and reaction design.  This presentation will focus on our recent efforts to design new reactions with a particular emphasis of redox-relay enantioselective Heck reactions,wherein exquisite control of migratory insertion and β-hydride elimination is required for a successful outcome.

Références :
a) Werner, E. W., Mei, T.-S., Burckle, A. J., Sigman, M. S. Science 2012, 338, 1455.  b) Mei, T.-S., Werner, E. W., Burckle, A. J., Sigman, M. S. J. Am. Chem. Soc. 2013, 135, 6830. c) Mei, T-S.; Patel. H. H. Sigman, M. S. Nature 2014, 508, 340. d) Xu, L.; Hilton, M. J.; Zhang, X.; Norrby, P.-O.; Wu, Y.-D.; Sigman, M. S.; Wiest, O. J. Am. Chem. Soc. 2014, 136, 1960.

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