Titre : Human Proteomes – From Basic Science to Understanding Drug Action.
Endroit : Pavillon Roger-Gaudry, salle G-715 à 11 h
Hôte : Professeur Pierre Thibault

Cette conférence sera prononcée par le Professeur Bernhard Küster, titulaire de la Chaire en en protéomique et bioanalyse au sein de la Technische Universität München. Elle est commanditée par la société Thermo Scientific et sera donnée en anglais.

Résumé : Proteomes are characterized by large protein-abundance differences, cell-type- and time-dependent expression patterns and post-translational modifications, all of which carry biological information that is not accessible by genomics or transcriptomics. In this talk, I will present the development of an advanced mass spectrometry based draft of the human proteome as well as a public, high-performance, in-memory database for real-time analysis of terabytes of big data, called ProteomicsDB. The information assembled from human tissues, cell lines and body fluids for instance enabled estimating the size of the protein-coding genome und uncovering an unexpected conserved relationship between mRNA and protein-expression. Furthermore, proteomic and chemoproteomic profiles of human cancer cells now allow predicting sensitivity of cancer drugs to molecularly targeted therapies as well as discovering mechanisms for resistance or sensitivity. Proteomic technology also allows tracking drug actions in cells and lysates on a target-class or proteome-wide scale with many implications for drug discovery and I will present examples for the identification of new uses of existing drugs, the identification of toxicity targets and the elucidation of the mechanism of action of drugs in cancer cells.

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